Aideen Ryan completed a PhD in Medicine from University College Cork. Her PhD research focused on the role of Fas Ligand and immune suppression in colon cancer. Dr. Ryan started her post-doctoral career in Prof. Laurence Egan’s lab at NUIG, where she studied the role of NF-kappaB in colon cancer metastasis using molecular and cellular technologies, as well as other disease models. Following this, Dr. Ryan moved to Prof Thomas Ritters Immunology Lab within the Regenerative Medicine Institute (REMEDI). Currently, Aideen is a visiting senior lecturer at Barts Cancer Institute, London.
Aideen has secured over €1,800,000 as PI /co-PI in independent internationally reviewed research funding, published over 28 peer-reviewed research papers, including 10 original research articles in the last 3 years. Dr. Ryan’s work has led to a number of significant publications which were the foundation to the acquisition of several recent prestigious independent grants, postdoctoral fellowships and international awards including Young Person of the Year Award (2019), Presidents Award for Research Excellence (2019), Research Paper of the Year Award (2019), Future Leader Award Cancer Immunotherapy SITC (2019), SFI Starting Investigator Research Award (2016), Haematology Association of Ireland Best Research Award (2016), a European Association for Cancer Research (EACR) Young Scientist Award (2015), 64th Lindau Nobel Laureate meeting Award (2014), Irish Cancer Society Research Fellowship (2013), and Best Research Presentation (2011), awarded by the Irish Society of Immunology.
Dr Ryan is an Editorial Board member of Frontiers in Tissue Engineering and Regenerative Medicine, and has co-edited special issues in International Journal of Molecular Sciences. She has served as an expert grant reviewer for Cancer Research UK (CRUK), Czech Science Foundation, Czech Republic. ‘Fonds voor Wetenschappelijk Onderzoek’ (FWO) Flanders, Belgium. She has reviewed research papers for over 15 journals, including Gut, Molecular Therapy and Oncogene.
Aideen’s research interests include understanding mechanisms of immune suppression and evasion in colon cancer, including analysis of colon cancer cells, immune cells and stromal cell interactions in the colon cancer microenvironment, with a particular focus on the influence of cancer cell NF-κB activity on macrophage/stromal cell polarization. Her research vision is to identify therapeutically targetable mechanisms of immune suppression in the tumour microenvironment, to enhance anti-tumour immune responses, and improve therapeutic outcomes to cancer.